Lazar Markovic returned from injury at the weekend and will give a welcome boost to the home side as they seek their first win in the competition.
The home side could be without Nani, however. The former Manchester United winger was forced off during their league match at the weekend and is now a major doubt for this fixture alongside Bruno Alves.
Robin van Persie hasn't had the best of starts to life in Turkey and has drawn a blank in each of Fenerbahce's last two Europa League matches. He could be replaced by Fernandao for this must win fixture.
Ajax
Frank de Boer could be without first-choice goalkeeper Jasper Cillessen for the trip to Turkey after he sat out Saturday's win over Heracles through injury sustained during international duty. This could give 35-year-old Diederik Boer a second consecutive start.
Arkadiusz Milik is also likely to miss out after returning from international duty injured as well.
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