Manchester United manager Louis van Gaal is sweating on the fitness of 10 players for the reception of PSV Eindhoven, though some should recover in time.
Injuries sustained to Ander Herrera and Phil Jones at the weekend mean they will miss out here. Wayne Rooney, Anthony Martial and Marouane Fellaini have all returned to full training and are back in contention to start.
Bastian Schweinsteiger was absent from training as part of United managing his workload, but he should be fine to start.
Memphis marked his return to the starting fold with a goal against Watford at the weekend and could lead the line here with Martial out wide.
PSV Eindhoven
Jetro Willems hasn't featured for the club this season and is likely to be absent once again as he continues his recovery from a serious knee injury sustained at the start of the summer.
Maxime Lestienne was given a special leave of absence at the start of October and hasn't featured since. His absence will damage PSV's chances of grabbing something from this match. He had played a direct hand in eight goals in six matches before becoming unavailable.
Menno Koch is also still out injured and Santiago Arias will incur a ban with his next booking. Hector Moreno can expect a hostile reception after breaking Luke Shaw's leg in the reverse fixture between the sides.
Prediction
Manchester United's Champions League campaign has been far from convincing but they are just one win away from booking their place in the next round of the competition. They will be looking to exact some revenge against PSV, whom they lost to on the opening round of the group stages.
Troy Deeney's spot-kick in the dying embers of their 2-1 win over Watford ended a run of 641 minutes without conceding for United, but they still haven't conceded a goal from open-play since their 1-1 draw with CSKA Moscow on 21 October.
PSV are also in a good position and will fancy their chances of going through to the next round. They are level with Wolfsburg in second place on six points and will have to CSKA Moscow at home in their final match, with Wolfsburg hosting United.
The reigning Dutch champions will be buoyed by United's injury crisis, but even then they may not have enough to overcome Louis van Gaal's men
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