Roma Kevin Strootman, Seydou Keita and Elio Capradossi are all sidelined for the Italian side. Club icon Francesco Totti will also miss out with the forward in a race to be fit for the derby against Lazio at the weekend. Daniele De Rossi is also a major doubt for the reception of Leverkusen.
William Vainqueur could come into the starting XI in De Rossi's absence. Miralem Pjanic was sent off at the weekend but his suspension will not impede his Champions League involvement. Bayer Leverkusen Charles Aranguiz and Roberto Hilbert are both sidelined for the Bundesliga outfit.
They are also sweating on the fitness of Lars Bender and Kevin Kampl for the trip to Rome.
Match Facts
Roma have drawn their last 3 matches against Leverkusen in all competitions. Roma draw 3.75 Roma have been drawing at both half time and full time in their last 3 matches against Leverkusen in all competitions. Roma draw/draw 6.50 There have been over 2.5 goals scored in Leverkusen's last 4 games in the Champions League (including qualifiers). Over 2.5 goals 1.62 Roma have failed to win their last 8 matches in the Champions League (including qualifiers).
Roma lose or draw 1.80 * Odds from Prediction The reverse fixture saw these two sides battle out an incredible 4-4 draw.
It's unlikely that there will be a repeat scoreline here but this match is very much up for the taking with neither side managing to put together a run of truly convincing performances. Roma's 1-0 defeat to Serie A rivals Inter at the weekend was their first defeat since the end of September in all competitions.
Bayer Leverkusen also come into this match off the back of a defeat, although their recent record reads three draws, two wins and a defeat in their last six outings in all competitions.
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